Resection and partial liver segment II/III transplantation with delayed total hepatectomy (RAPID) is a surgery that combines the advantages of two-step hepatectomy with associating liver partition and portal vein ligation (ALPPS) and auxiliary liver transplantation. The surgery is mainly used to treat noncirrhotic liver diseases such as nonresectable colorectal liver metastases (nrCRLM) and cirrhotic liver diseases with portal hypertension. The concept and procedure of this surgery was innovated with a dramatic improvement of treatment of nrCRLM by liver transplantation. The aim of this surgery is to alleviate the shortage of liver allograft and the allocation of donor livers. The protocol of the RAPID includes left liver resection, implantation of left lateral graft, and modulation of portal flow to the graft in the phase 1. During the interphase, regeneration of volume and function of the liver graft is monitored. Remnant right liver resection is completed in the phase 2. The technical development of RAPID includes living donor-RAPID and RAVAS. However, compared with classical liver transplantation, RAPID requires more experience accumulation and strict risk management. It is of most importance to evaluate RAPID procedure by multi-center clinical trials and long-term postoperative follow-up.