Medical genetics is an interdisciplinary subject that combines classical genetics with clinical medicine. It plays an important role in modern medical education. In order to further improve the teaching quality of the medical genetics course, enhance students' learning interest, and build a solid medical genetics knowledge system, the teaching team combined the teaching experience and teaching improvement process in recent years to explore the application of various teaching methods in medical genetics teaching based on the traditional lecture teaching method, according to the students' learning stage and the difficulty of knowledge points. This paper discusses the application of online and offline hybrid teaching mode, flipped classroom teaching mode, team learning and problem-based learning teaching mode in the teaching of medical genetics. It is not limited to letting students master basic theoretical knowledge, but also to stimulate students' interest in medical genetics, enhance their enthusiasm for learning, and enable them to think independently during the course learning process, from passive acceptance to active pursuit of knowledge. At the same time, it also provides new ideas for efficient teaching methods of medical genetics in the new era.