Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Colorectal cancer liver metastasis (CRLM) is the leading cause of death. Recently, more and more attention has been paid to the role of lipid metabolism in CRLM. High-fat diet is considered to be one of the important factors inducing CRLM. It is closely related to the accumulation of visceral fat, and then affects the occurrence and development of tumors. In addition, the role of lipid-lowering drugs in regulating lipid metabolism and improving metabolic syndrome also provides a new strategy for the prevention and treatment of liver metastasis of colorectal cancer. This review will explore the complex network of lipid metabolism, and analyzes the effects of high-fat diet, visceral fat and lipid-lowering drugs on liver metastasis of colorectal cancer, so that provides the directions for future research.