To investigate the safety of laparoscopic surgery for colorectal cancer patients aged ≥80 years old. Methods Clinical data of 270 elderly colorectal cancer patients undergoing laparoscopic surgery in our hospital from January 2023 to January 2025 were retrospectively analyzed. The patients were divided into a control group (65 ~79 years old, n=200) and an observation group (≥80 years old, n=70). After propensity score matching, 70 patients were successfully included in each group (1 ∶ 1 ratio). Both groups underwent standard laparoscopic radical resection for colon or rectal cancer under general anesthesia. Baseline characteristics, operative duration, intraoperative blood loss, time to first flatus, hospital stay and 30-day postoperative complications were compared between the two groups. Results No statistically significant differences in operative duration, intraoperative blood loss and time to first flatus postoperatively between the two groups (P>0. 05). The observation group exhibited a significantly longer postoperative hospital stay than the control group (P< 0. 05). No significant difference was found in overall postoperative complication rates between the two groups (P> 0. 05). Conclusions Laparoscopic surgery demonstrates feasibility and safety for colorectal cancer patients aged ≥80 years old. With rigorous preoperative evaluation and enhanced perioperative management, laparoscopic surgery represents a favorable therapeutic option for elderly colorectal cancer patients. It is worth promoting.