Abstract:Objective To summarize the effectiveness and safety of balloon-assisted enteroscopy ( BAE) in the treatment of patients with small intestinal bleeding caused by jejunal and ileal arteriovenous malformations (AVMs). Methods Twenty patients diagnosed as isolated jejunal AVM-induced small intestinal bleeding and undergone endoscopic treatment from April 2016 to December 2024 were selected. According to types of endoscopic intervention, the patients were divided into a sclerotherapy group and an argon plasma coagulation (APC) group. The sclerotherapy group was treated with endoscopic sclerotherapy combined with hemoclips. The APC group was treated with argon plasma coagulation combined with hemoclips. All patients received long-term follow-up after treatment. Their hemostatic effect and rebleeding risk were evaluated. Results The 20 patients with small intestinal bleeding were diagnosed as arteriovenous malformations ( AVM). Among the patients, 16 patients agreed to receive endoscopic treatment, 2 patients chose surgical treatment, and 2 patients refused intervention. The rebleeding rates in endoscopic treatment after 3, 6 and 12 months were 18. 75% (3 / 16), 25% (4 / 16) and 43. 75% (7 / 16), respectively. Compared with the sclerotherapy group and the APC group, the rebleeding rates after 3, 6 and 12 months were 27. 27% vs. 0% , 36. 36% vs. 20% , and 36. 36% vs. 60% , respectively. The differences were not statistically significant ( P>0. 05). Conclusions Endoscopic treatment under BAE has good hemostatic effect and low rebleeding risk in patients with small intestinal bleeding caused by jejunal and ileal AVMs. Both sclerotherapy combined with hemostatic clips and APC combined with hemostatic clips are safe and feasible endoscopic treatment methods. The two methods have similar short-term efficacy. However, endoscopic sclerotherapy may have certain advantages in long-term efficacy