经气囊辅助小肠镜治疗小肠动静脉畸形出血疗效及安全性研究
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李白容,女,博士,副主任医师,硕士研究生导 师。 北京医学会内镜分会青年委员,北京医学会消化分会青年论 坛委员,中国医药教育协会消化内镜分会青年委员会副主任委 员。 主要研究方向:小肠疾病内镜诊治。

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首都卫生发展科研专项资助项目 ( 编号:首发2020-4-5123)


A study on the efficacy and safety of balloon-assisted enteroscopy in the treatment of small intestinal arteriovenous malformation bleeding
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    摘要:

    目的 总结经气囊辅助小肠镜(balloon-assissted enteroscopy,BAE)对空肠和回肠动静脉畸形( arteriovenous malformation,AVM)所致小肠出血患者的治疗有效性和安全性。 方法 2016 年 4 月至 2024 年 12 月确诊孤立性空回肠 AVM 所致 小肠出血并接受内镜治疗的 20 例患者。 根据内镜干预方式不同,将患者分为内镜下硬化剂治疗联合止血夹组(硬化剂组)和 氩等离子体凝固术(APC)联合止血夹组(APC 组);所有患者在治疗后均接受长期随访,评估其止血效果及再出血情况。 结果 20 例小肠出血患者经 BAE 诊断为 AVM,其中 16 例同意接受内镜治疗,2 例选择手术治疗,2 例拒绝干预。 在内镜治疗中 3、6、 12 个月再出血率分别为 18. 75% (3 / 16)、25% (4 / 16)、43. 75% (7 / 16)。 对硬化剂组和 APC 组进行比较,3、6、12 个月再出血 率分别为 27. 27% vs 0% 、36. 36% vs 20% 、36. 36% vs 60% ,差异无统计学意义(P>0. 05)。 结论 BAE 下实施内镜治疗在空肠 和回肠 AVM 所致小肠出血患者中具有良好的止血效果及较低的再出血风险;硬化剂联合止血夹与 APC 联合止血夹均为安 全、可行的内镜治疗手段,两者短期疗效相近,但内镜下硬化剂治疗在远期疗效方面可能具有一定优势。

    Abstract:

    Objective To summarize the effectiveness and safety of balloon-assisted enteroscopy ( BAE) in the treatment of patients with small intestinal bleeding caused by jejunal and ileal arteriovenous malformations (AVMs). Methods Twenty patients diagnosed as isolated jejunal AVM-induced small intestinal bleeding and undergone endoscopic treatment from April 2016 to December 2024 were selected. According to types of endoscopic intervention, the patients were divided into a sclerotherapy group and an argon plasma coagulation (APC) group. The sclerotherapy group was treated with endoscopic sclerotherapy combined with hemoclips. The APC group was treated with argon plasma coagulation combined with hemoclips. All patients received long-term follow-up after treatment. Their hemostatic effect and rebleeding risk were evaluated. Results The 20 patients with small intestinal bleeding were diagnosed as arteriovenous malformations ( AVM). Among the patients, 16 patients agreed to receive endoscopic treatment, 2 patients chose surgical treatment, and 2 patients refused intervention. The rebleeding rates in endoscopic treatment after 3, 6 and 12 months were 18. 75% (3 / 16), 25% (4 / 16) and 43. 75% (7 / 16), respectively. Compared with the sclerotherapy group and the APC group, the rebleeding rates after 3, 6 and 12 months were 27. 27% vs. 0% , 36. 36% vs. 20% , and 36. 36% vs. 60% , respectively. The differences were not statistically significant ( P>0. 05). Conclusions Endoscopic treatment under BAE has good hemostatic effect and low rebleeding risk in patients with small intestinal bleeding caused by jejunal and ileal AVMs. Both sclerotherapy combined with hemostatic clips and APC combined with hemostatic clips are safe and feasible endoscopic treatment methods. The two methods have similar short-term efficacy. However, endoscopic sclerotherapy may have certain advantages in long-term efficacy

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赖文财,夏至波,冯小萌,黄滋涵,宁守斌,李白容.经气囊辅助小肠镜治疗小肠动静脉畸形出血疗效及安全性研究[J].实用医院临床杂志,2025,22(5):45-51

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  • 收稿日期:2025-07-01
  • 最后修改日期:2025-07-24
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  • 在线发布日期: 2025-09-29
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