1型糖尿病患儿的身高增长与营养代谢指标的关系
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曹艳丽,女,硕士,副主任医师。中国医师协会医学遗传医师分会第三届委员遗传代谢学组组员,山东省抗癫痫协会药物治疗专业委员会委员,山东省研究型医院学会儿科神经系统罕见病分会委员,山东省疼痛医学会委员,济南市神经内科专业委员会委员。主要研究方向:儿童神经、代谢性疾病。

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国家重点研发计划项目(编号:2022YFC2703401)


The relationship between height growth and nutritional metabolism indicators in children with type 1 diabetes
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    目的 探索 1 型糖尿病(T1DM)患儿的身高发育与营养代谢指标的关系。方法 选择 2021 年 12 月至 2025 年 5 月济南市儿童医院内分泌科收治的 124 例 T1DM 患儿的临床资料及代谢生化结果,按病程分为确诊 1 年以内组、确诊 1 年以上组,回顾性分析两组患儿的身高标准差评分(身高 SDS)与营养代谢指标的相关性。结果 在未纠正以及纠正相关因素时,确诊 1 年以内组患儿的身高 SDS 与实验室指标未见明显相关性,确诊 1 年以上组身高 SDS 与血清尿酸以及血清尿酸百分位数值有相关性(P<0.05)。在多重线性回归分析中,确诊大于 1 年组身高 SDS 随血清尿酸以及血清尿酸百分位数值升高而升高(β=0.005,P=0.032 以及 β=0.012,P=0.025)。结论 患儿的身高 SDS 与血清尿酸水平正相关,需要进一步研究以确定其作为 T1DM 管理的监测工具的作用。

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    Objective To explore the relationship between height growth and nutritional metabolic indicators in children with type 1 diabetes mellitus (T1DM). Methods Clinical data and metabolic biochemical results of 124 children with T1DM admitted to the department of endocrinology of Jinan Children's Hospital from December 2021 to May 2025 were selected. According to the course of disease, the sick children were divided into a diagnosed within 1 year group and a diagnosed more than 1 year group. The correlation between height standard deviation score (height SDS) and nutritional metabolic indexes in the two groups was retrospectively analyzed. Results When not corrected and when relevant factors were corrected, there was no significant correlation between the height SDS and the laboratory indicators in the diagnosed within 1 year group. However, there was a correlation between the height SDS and the serum uric acid and the percentile value of serum uric acid in the diagnosed more than 1 year group (P<0.05). In the multiple linear regression analysis, the height SDS in the diagnosed more than 1 year group increased with the increase of serum uric acid and the percentile value of serum uric acid (β=0.005, P=0.032 and β=0.012, P=0.025). Conclusions Height SDS of children with T1DM is positively correlated with serum uric acid level. Further studies are needed to determine its role as a monitoring tool for T1DM management.

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孙文慧,曹艳丽,杨艳玲,等.1型糖尿病患儿的身高增长与营养代谢指标的关系[J].实用医院临床杂志,2026,23(1):36-40

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  • 收稿日期:2025-10-15
  • 最后修改日期:2025-10-19
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  • 在线发布日期: 2026-02-12
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