The incidence of mental health problems among inpatients in general hospitals is as high as 20% ~ 40%. However,both recognition and treatment rates remain below 20%. Establishing effective proactive screening and early intervention systems forhigh-risk populations is an effective approach to enhancing mental health service capacity in healthcare institutions. Since 2021,Guangdong province has implemented a “Happiness hospital” program and developed an integrated model based on two-stage screeningand stepped care. Brief screening instruments are used for initial assessment, followed by secondary stratified assessment with interna-tionally validated scales for patients who screen positive. Stepped interventions are delivered through collaboration between mentalhealth specialists and specially trained “Happiness nurses”. A digital management platform to achieve full process management was established. Across five pilot hospitals, more than 20000 patients were enrolled. In a prospective study conducted at Panyu District Central Hospital (n = 3685), psychological assessments were performed at admission and prior to discharge. The results showed that the overall detection rate of mental health problems were decreased from 24. 0% at admission to 16. 6% before discharge. Specifically, detection rates of depression, anxiety and insomnia were decreased by 4. 9%, 2. 5% and 5. 4%, respectively. Suicide risk was reducedby 0. 8%. Through the establishment of standardized tools, dedicated roles and a digital management platform, the program hasstrengthened the service concept of " treating both body and mind" for non-psychiatric medical staff in general hospitals. Thereby, areplicable “Guangdong model” is formed.