Syphilis is a sexual infectious disease,which has extremely complex manifestations and severely threatens human health.Laboratory test is the main method to diagnose and find Syphilis and Serology Test is one of the important evidences to diagnose Syphilis,which has important significance in diagnosis,treatment and research.Therefore,correct understanding and evaluation of Syphilis Serology Test have very important meaning when guiding the practice.This article has reviewed the current development and application of Syphilis Serology Test in the world.